A contactless conductivity method with microfluidic chip was established for the rapid determination of memantine hydrochloride in memantine hydrochloride tablet.Effects of electrophoresis parameters such as variety,concentration,pH value of buffer solution,injection time and separation voltage on the separation detection were investigated.The optimized buffer system was 3.0 mmol/L triethylamine-2.0 mmol/L phosphate buffer solution(pH 3.3) containing 2%(by volume) dimethyl sulfoxide(DMSO),the injection time was 10 s and the separation voltage was 2.0 kV.In the optimal conditions,the linear range for memantine hydrochloride was 10-2 000 μg/mL(r2=0.999 1).The limits of detection and quantitation were 7 μg/mL and 10 μg/mL,respectively.Relative standard deviations for precision,stability and reproducibility tests were lower than 2.0%,and average recoveries for memantine hydrochloride were in the range of 96.5%-99.2%,with a detection time less than 18 s.The method is rapid and simple,and is suitable for the determination of memantine hydrochloride in memantine hydrochloride tablet.