Preparation and Uncertainty Valuation of Naringenin Certified Reference Material

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Preparation and Uncertainty Valuation of Naringenin Certified Reference Material

更新时间：2023-05-25

- Preparation and Uncertainty Valuation of Naringenin Certified Reference Material
- Vol. 39, Issue 2, Pages: 190-197(2020)
- 作者机构：
  
  1. 西南大学化学化工学院
  2. 中国农业科学院/西南大学柑橘研究所
  3. 农业农村部柑橘产业质量安全风险评估实验室
- 作者简介：
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Preparation and Uncertainty Valuation of Naringenin Certified Reference Material. [J]. 39(2):190-197(2020)
DOI：

Preparation and Uncertainty Valuation of Naringenin Certified Reference Material. [J]. 39(2):190-197(2020) DOI：

摘要

建立了柚皮素标准物质的研制和定值方法。通过红外光谱和核磁共振氢谱对样品进行定性分析，经过柱层析纯化、干燥、混匀后，分装得到120瓶样品。采用质量平衡法和差示扫描量热法进行定值分析(质量平衡法包括液相色谱面积归一化法、水分、无机杂质和残留溶剂的测定)。运用液相色谱法考察了样品的均匀性和稳定性，并对定值结果进行了不确定度评定。结果显示，研制的柚皮素标准物质具有良好的均匀性和稳定性，定值结果为99.2%，扩展不确定度为0.2%，有效期6个月。

Abstract

A method for preparation and determination of naringenin certified reference material was established.Qualitative analysis of purchased samples was performed using infrared spectroscopy and nuclear magnetic resonance.The samples were purified by column chromatography and dried at 105 ℃ for 6 h,after mixing and dispensing,120 bottles of reference material candidates were obtained.Purity determination was carried out by differential scanning calorimetry and mass balance method.The mass balance method based on area normalization method of liquid chromatography,included detections on contents of moisture,inorganic impurities and residual solvents.Homogeneity and stability studies were validated by liquid chromatography,and uncertainty of the determination results was also analyzed.Results showed that the developed naringenin certified reference material had good homogeneity and stability,with a purity of 99.2%,an expanded uncertainty of 0.2%(k=2) and a validity period of 6 months.

关键词

柚皮素定性分析标准物质不确定度

Keywords

naringeninqualitative analysiscertified reference materialsuncertainty

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Zhongshan Zhongzhi Pharmaceutical Group Co.，Ltd.

Guangdong Provincial Engineering Research Center for Quality and Safety of Traditional Chinese Medicine，Guangdong Provincial Key Laboratory of Chemical Measurement and Emergency Test Technology， Institute of Analysis，Guangdong Academy of Sciences（China National Analytical Center，）

National Reference Laboratory for Food Contact Material（Guangdong），Guangzhou Customs District Technology Center

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