According to the demand of home-made spectrometer,a radio frequency（RF） signal amplifier was developed.This RF signal amplifier,composed of amplifier circuit module and coupling coil,could combine with RF signal generator to drive the radio frequency quadrupole（RFQ）.The amplifier can carry out 30 times magnification,and provide resonance frequency of 1.4 MHz,peak to peak voltage Vp-p of 0-600 V RF signals for self-made RFQ.The developed RFQ was used to transmit the ions generated in atmospheric pressure ion source to a home-made desktop orthogonal-in-jection time-of-flight mass analyzer.With the radio frequency signal amplifier described in this paper,the ions with m/z equal to 30-600 amu can be transmitted efficiently.