A liquid chromatography-mass spectrometric(LC-MS） method was established for the determination of six estrogens in drinking water.The sample was extracted with acetonitrile，enriched by Oasis HLB solid phase extraction column，and then analyzed by LC-MS.Under the optimal conditions，good linearities were obtained in the range of 5-100 μg/L for six estrogens with correlation coefficients of 0.994-1.000.The detection limits for 6 estrogens were all 0.1 μg/L.The recoveries at three spiked levels of 0.10，25,50 μg/L were between 85% and 95% with relative standard deviations less than 10%.With the advantages of high sensitivity and simple sample preparation without matrix interference,the method was suitable for the analysis of the estrogens in drink water.