A high performance liquid chromatographic(HPLC) method was developed for the determination of antioxidant D in pressure sensitive adhesive and its products．The sample was dissolved with ethyl acetate，then precipitated by methanol.The extract was centrifugally separated for 5 min at a speed of 3 000 r/min．After filtrated with filter membrane，the supernatant was separated on a C18 column by isocratic elution using acetonitrile-water as mobile phase at a flow rate of 0.5 mL/min，and determined by HPLC with diode-array detector(DAD)at 310 nm，quantified by the external standard method．The conditions of sample pretreatment and chromatographic separation were optimized，and the confirmatory method of mass spectrometry used to quantitatively determine antioxidant D in the sample was established．Under the optimal conditions，the method showed good linearities between peak areas and the contents in the ranges of 0.01-1 mg/L and 1-100 mg/L for antioxidant D，with a limit of quantitation of 1 mg/kg．The established method was applied in the determination of antioxidant D in emulsion-type pressure-sensitive adhesive，hotmelt-type pressure-sensitive adhesive and solvent-type pressure-sensitive adhesive，and the spiked recoveries ranged from 96% to 100% with relative standard deviations(RSDs) of 1.1%- 3.1%．The results indicated that this method was reliable，sensitive and repeatable，and could meet the requirement for analysis of antioxidant D in the pressure sensitive adhesive and its products.