An ultra performance liquid chromatography-tandem mass spectrometric（UPLC-MS/MS） method was developed for the determination of sucralose in foodstuffs.The sample was extracted with water.Different purificatory methods like HLB cartridge purification or precipitators removing fat and protein were chosen according to different sample matrixs.The extract was separated with reversed-phase UPLC column using a binary eluent under isocratic conditions,and determined by tandem mass spectrometry under negative electrospray ionization mode with multiple reaction monitoring （MRM） mode. m/z 395.07/358.90 and m/z 397.07/360.90 were selected as two precursor-product ion pairs,in which m/z 395.07/358.90 was used for quantization.Under the optimal conditions,the calibration curve was linear over sucralose concentration in the range of 0.2-20 mg/L with quantitation limit of 0.4 mg/kg.The average recoveries of sucralose from Chinese spirit,modified milk and fried peanut kernels at three spiked levels of 0.4,4,10 mg/kg ranged from 85% to 98% with relative standard deviations （n=6） of 1.7%-5.0%.The method showed good simplicity,sensitivity and stability,and was suitable for the rapid determination of sucralose in foodstuffs.