Based on the fact that venlafaxine had remarkable enhancing effect on Ag（Ⅲ） complex-luminol chemiluminescence（CL） system，a novel method for the determination of venlafaxine was established by CL method with flow-injection analysis.Under the optimum conditions，the calibration curve was linear in the range of 0.1-2.0 mg?L-1 with detection limit（S/N=3） of 0.05 mg?L-1.The relative standard deviation（n=11） for 0.1 mg?L-1 venlafaxine was 0.87%，and the recovery ranged from 96% to 105%.This method was simple，sensitive and accurate，and was successfully applied in the determination of venlafaxine in capsules.