Synthesis of β-Cyclodextrin Derivative with Allyl and Methyl on the 3-Positions and Its Capillary Gas Chromatographic Properties

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Synthesis of β-Cyclodextrin Derivative with Allyl and Methyl on the 3-Positions and Its Capillary Gas Chromatographic Properties

- Synthesis of β-Cyclodextrin Derivative with Allyl and Methyl on the 3-Positions and Its Capillary Gas Chromatographic Properties
- Vol. 31, Issue 2, Pages: 138-142(2012)
- 作者机构：
  
  1. 中央民族大学中国少数民族传统医学研究院中国少数民族传统医学国家民委—教育部重点实验室
  2. 中国农业大学应用化学系
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Synthesis of β-Cyclodextrin Derivative with Allyl and Methyl on the 3-Positions and Its Capillary Gas Chromatographic Properties. [J]. 31(2):138-142(2012)
DOI：

Synthesis of β-Cyclodextrin Derivative with Allyl and Methyl on the 3-Positions and Its Capillary Gas Chromatographic Properties. [J]. 31(2):138-142(2012) DOI：

摘要

制备了一种新的β-环糊精衍生物固定相2，6-二-O-戊基-3-O-［(甲基)5-(烯丙基)2］-β-CD，并对其气相色谱分离性能进行研究。实验显示，该固定相具有良好的柱表面性能和较强的色谱分离能力，对一些芳香族位置异构体的分离能力优于2，6-二-O-戊基-3-O-烯丙基-β-CD衍生物，对10余种手性物质显示出较好的选择性能，且对α-位取代的丙酸酯类手性分离效果明显优于杂环类β-CD衍生物。与2，6-二-O-戊基-3-O-烯丙基-β-CD固定相的分离性能比较表明，β-CD 3位羟基部分甲基基团的引入能增强对芳香族位置异构体的选择能力，但不能明显改变烯丙基衍生物的手性分离能力。

Abstract

A new β-cyclodextrin(β-CD) derivative，2，6-di-O-pentyl-3-O-［(methyl)5 (allyl)2］-β-CD was synthesized.The chromatographic properties of this β-CD derivative were examined and studied by using as a chiral stationary phase in capillary gas chromatography，which showed a good separation ability and a chiral selectivity.Nine kinds of aromatic positional isomers were successfully separated with good resolutions，and parts of their separation results were better than that of 2，6-di-O-pentyl-3-O-allyl-β-CD and other β-CD derivatives.And meanwhile，more than ten kinds of chiral compounds were also determined on this stationary phase.Especially，the separations of some propanoic acid esters with α-substitute were better than those on heterocyclic β-CD derivatives reported in the literature.However，the experimental results showed the chiral separation ability of this stationary phase was still similar to the 2，6-di-O-pentyl-3-O-allyl-β-CD by comparison.It indicated that the introduction of methyl to the part of C3-OH positions may improve the selectivity to aromatic positional isomers，but could not affect obviously the chiral separation ability of the β-CD derivative modified allyl groups on the whole of the C3-OH positions.

关键词

毛细管气相色谱β-环糊精衍生物手性分离

Keywords

capillary gas chromatographyβ-cyclodextrin derivativechiral separation

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