A molecularly imprinted polymer（MIP）,which has a specific selectivity to dopamine，was synthesized using dopamine as template and 3-aminopropyltriethoxysilane modified mesoporous silica as carrier.The MIP was used to fabricate a sensor for the determination of dopamine,which response to dopamine（DA） was evaluated by cyclic voltammetry.Under the optimized conditions，the sensor displayed good linearities in the ranges of 1.0×10-7-2.0×10-6 mol/L and 2.0×10-6-1.0×10-4 mol/L with a lower detection limit of 1.3×10-9 mol/L.The correlation coefficients were 0.992 5 and 0.996 9，respectively.The studied imprinted sensor exhibited high sensitivity and selectivity，and was successfully applied in the determination of dopamine in human blood plasma.