An anion-exchange monolithic column was prepared by a polymerization inside a stainless steel tube(150 mm×4.6 i.d.mm),taking glycidyl methacrylate(GMA) as functional monomer,ethylene dimethacrylate(EDMA) as cross-linking agent and in the presence of 1,4-butanediol,1-propanol and water as the porogen solvents and azobisisobutyronitrile(AIBN) as a suitable initiator.Introduction of anion-exchange sites were achieved by reacting with tirmethylamine.Under the optimized reaction conditions and the modified conditions,the chromatographic characteristics of the prepared anion-exchange columns were further studied,and the separation of 5 common anions (such as,acetate,bromate,nitrite,bromide,nitrate) on the prepared anion-exchange column was investigated.The prepared column exhibits more advantages such as simple preparation and low cost,and could be coupled with a commercial ion chromatography system directly,which will be favorable for more applications and investigations.