Electrochemical Behavior and Determination of Paracetamol at Molecular Imprinted Film Modified Glassy Carbon Electrode

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Electrochemical Behavior and Determination of Paracetamol at Molecular Imprinted Film Modified Glassy Carbon Electrode

- Electrochemical Behavior and Determination of Paracetamol at Molecular Imprinted Film Modified Glassy Carbon Electrode
- Vol. 31, Issue 5, Pages: 589-592(2012)
- 作者机构：
  
  1. 广东药学院药科学院
  2. 中山大学化学与化学工程学院
- 作者简介：
- 基金信息：
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Electrochemical Behavior and Determination of Paracetamol at Molecular Imprinted Film Modified Glassy Carbon Electrode. [J]. 31(5):589-592(2012)
DOI：

Electrochemical Behavior and Determination of Paracetamol at Molecular Imprinted Film Modified Glassy Carbon Electrode. [J]. 31(5):589-592(2012) DOI：

摘要

以对乙酰氨基酚（PCT）为模板分子，甲基丙烯酸为功能单体，采用光引发原位聚合法在玻碳电极（GCE）表面聚合成膜，以甲醇-甲酸将模板分子洗脱，制得对乙酰氨基酚分子印迹膜修饰电极（MIP-GCE），建立了该电极直接测定PCT的分析方法。结果表明，该传感器具有较高的选择性和灵敏度，PCT浓度在5.0×10-5~1.0×10-3 mol?L-1范围内与其峰电流呈良好的线性关系，检出限为1.4×10-6 mol?L-1。应用该法测定药物中PCT的含量，在干扰物质共存情况下的回收率为96%~105%。

Abstract

Using paracetamol（PCT） as template and methylacrylic acid as functional monomer, a molecular imprinted polymer film was synthesized on the surface of glassy carbon electrode（GCE） through in-situ polymerization by UV irradiation.After the template was removed with methanol and formic acid mixture solution, a paracetamol imprinted polymer film modified glassy carbon electrode（MIP-GCE） was prepared, and a method for the determination of PCT was developed with MIP-GCE.The sensor exhibited a good selectivity and sensitivity.The calibration curve was linear in the range of 5.0×10-5-1.0×10-3 mol?L-1 with a detection limit of 1.4×10-6 mol?L-1.The method was applied in the determination of PCT in drugs, with recoveries of 96%-105%.

关键词

对乙酰氨基酚分子印迹膜玻碳电极电化学原位聚合光引发

Keywords

paracetamolmolecular imprinted filmglassy carbon electrodeelectrochemistryin-situ polymerizationUV irradiation

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Key Laboratory of Low-carbon Chemistry & Energy Conservation of Guangdong Province，Sun Yat-sen University

School of Chemistry，Sun Yat-sen University

School of Mechanical and Automotive Engineering，South China University of Technology

中国地质大学(武汉)材料化学学院

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