A sweeping-micellar electrokinetic chromatographic（sweeping-MEKC） method was used for the simultaneous separation and determination of chlorphenamine maleate，caffeine and acetaminophen in compound paracetamol and amantadine hydrochloride capsules.Effects of sodium dodecyl sulfate（SDS） concentration,separation voltage,injection time of sample,composition and concentration of background buffer on separation efficiency were optimized.An optimal separation of three compounds was obtained on an uncoated fused silica capillary column（50 cm×50 μm,effective length 35 cm） by using background buffer containing 80 mmol/L SDS,20 mmol/L NaH2PO4 and 15% acetonitrile at pH 2.2 with a constant temperature of 25 ℃.The detection wavelength was set at 210 nm,the separation voltage at-20 kV and the sample injection time for 60 s.The result indicated that the separation of three compounds was performed within 25 min with relative standard deviation（RSDs） of their peak areas less than 4%.The calibration curves showed good linearities in the ranges of 2.45-39.17 mg/L for chlorphenamine,1.61-25.76 mg/L for caffeine and 1.58-25.28 mg/L for acetaminophen,with detection limits（S/N=3） of 139,34,24 μg/L,respectively.The spiked recoveries for acetaminophen,caffeine and chlorphenamine maleate were 96%-101%,98%-102% and 96%-102%,respectively.