A method was established for the determination of chlordimeform and its metabolite 4-chloro-2-methylaniline residues in foods of animal by GC-MS.Five kinds of foods derived from animal(e.g.tilapia muscle,chicken liver,pork,shrimp and beef ) were extracted with ethyl acetate in alkaline conditions(pH≥11.0).The extracts were purified with the graphitization carbon black cartridge(GCB SPE，250 mg/3 mL) and neutral alumina solid phase cartridge(Al2O3 SPE，2.0 g/3 mL),and then determined by GC-MS.Good linear relationships were obtained between the peak areas and the concentrations of chlordimeform and its metabolite 4-chloro-2-methylaniline within the range of 10-500 μg/L,with correlation coefficients of 0.999 1 and 0.998 7,respectively.The recoveries were in the ranges of 81%-119% for chlordimeform,and 80%-119% for 4-chloro-2-methylaniline,with RSDs(n=6) of 1.1%-11.7% and 2.0%-13.7%,respectively.The results showed that the quantitation limits for the two compounds were both 10.0 μg/kg.The proposed method was accurate,sensitive and high-efficient,and was applicable in the determination of chlordimeform and its metabolite in animal derived foods.