Confirmation of the Structure of a New Sildenafil Analogue

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Confirmation of the Structure of a New Sildenafil Analogue

- Confirmation of the Structure of a New Sildenafil Analogue
- Vol. 32, Issue 4, Pages: 488-483(2013)
- 作者机构：
  
  1. 广东工业大学轻工化工学院
  2. 中国广州分析测试中心广州法尔麦兰药物技术有限公司
  3. 中国广州分析测试中心广东省化学危害应急检测技术重点实验室
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Confirmation of the Structure of a New Sildenafil Analogue. [J]. 32(4):488-483(2013)
DOI：

Confirmation of the Structure of a New Sildenafil Analogue. [J]. 32(4):488-483(2013) DOI：

摘要

采用核磁共振氢谱（1H NMR）、核磁共振碳谱（13C NMR）、梯度场氢氢相关化学位移相关谱（1H-1H COSY）、梯度场质子检测异核单量子化学位移相关谱（HSQC）、梯度场质子检测异核多重键化学位移相关谱（HMBC）等多种NMR分析方法，结合红外光谱分析和元素分析，确证了5-［2-丙氧基-5-（3,5-二甲基哌嗪-1-基磺基）苯基］-1-甲基-3-正丙基-1,6-二氢-7H-吡唑并［4,3-d］嘧啶-7-酮的分子结构，为鉴定西地那非类似物提供了重要依据。

Abstract

The molecular structure of 5-［2-propoxy-5-（3,5-dimethylpiperazin-1-yl-sulfonyl）phenyl］-1- methyl-3- n-propyl-1,6-dihydro-7H-pyrazol［4,3-d］pyrimidin-7-one was elucidated by 1D NMR（1H,13C NMR） and 2D NMR techniques，including gradient homonuclear correlation spectroscopy（1H-1H COSY）,gradient heteronuclear single-quantum coherence（HSQC） and gradient heteronuclear multiple-bone coherence（HMBC）,together with the infrared spectral analysis and elementary analysis.The 1H NMR and 13C NMR signals for 5-［2- propoxy-5-（3,5- dimethyl- piperazin-1- yl-sulfonyl）phenyl-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazol［4,3-d］pyrimidine-7-one were assigned.The data obtained could be used to detect sildenafil analogues.

关键词

一维NMR谱二维NMR谱归属定性分析

Keywords

1D NMR2D NMRassignmentqualitative analysis

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Zhongshan Zhongzhi Pharmaceutical Group Co.，Ltd.

Guangdong Provincial Engineering Research Center for Quality and Safety of Traditional Chinese Medicine，Guangdong Provincial Key Laboratory of Chemical Measurement and Emergency Test Technology， Institute of Analysis，Guangdong Academy of Sciences（China National Analytical Center，）

National Reference Laboratory for Food Contact Material（Guangdong），Guangzhou Customs District Technology Center

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