An online SPE coupled with HPLC method was developed for the determination of chlorogenic acid and phillyrin in ShuangHuangLian oral liquid and capsule.Acclaim Polar AdvantageⅡC18（4.6 mm×50 mm×3 μm）was used as online one dimensional column with a mobile phase consisting of methanol-1% acetic acid-water by gradient elution with a right pump at a flow rate of 0.8 mL/min.The left pump was used to analyze the elute in SPE using Acclaim C18（4.6 mm×150 mm×5 μm）as its two dimensional analytical column by gradient elution with acetonitrile-1% acetic acid-water as mobile phase at a flow rate of 1.0 mL/min.The UV detector was set at 278 nm.Good linear relationships were observed between peak areas and concentrations in the ranges of 0.021-0.42 g/L for chlorogenic acid and 0.014-0.28 g/L for phillyrin，with correlation coefficients of 0.999 5 and 0.999 7，respectively.The average recoveries of phillyrin and chlorogenic acid in ShuangHuangLian oral liquid were 100% and 99%，respectively.This method was simple and fast,and had good speciality and repeatability.