Eight sulfonamides，including sulfamethazine（SMZ），sulfathiazole（ST），sulfamonomethoxine（SMM-Na），sulfachloropyridazine（SCP），sulfafurazole（SIZ），sulfadimethoxine（SDM），sulfaphenazolum（SPP） and sulfanitran（SNT） in poultry and liver，were extracted by silica-supported ionic liquid-based matrix solid phase dispersion（S-ILs-MSPD），and determined by high performance liquid chromatography（HPLC）.The experimental conditions for the matrix solid phase dispersion extraction were optimized.The optimal conditions were as follows:dispersant:silica-supported ionic liquid containing 12% 1-hexyl-3-methylimidazolium hexafluorophosphate（［Hmim］PF6），washing solvent:petroleum ether，elution solvent:methanol.ratio of dispersant to sample:4∶1.Good linear relationships for eight sulfonamides were obtained in the range of 25-1 000 μg/kg with correlation coefficients not less than 0.997 4.The limits of detection and limits of quantitation of eight sulfonamides were in the ranges of 4.4-7.6 μg/kg and 14.7-25.3 μg/kg，respectively.The average recoveries ranged from 66. 2% to 98.7% with relative standard deviations（n=6） of 1.4%-9.0%.Compared with other extraction techniques，the present method has the advantages of low consumption and high sensitivity，and is suitable for the detection of sulfonamide residues in poultry products.