A method was developed for the determination of 11 perfluorinated compounds (PFCs) (e.g.perfluorobutanesulfonate,perfluorohexane-sulfonate,perfluoroheptanoic-acid,perfluorooctanoate,perfluorooctane-sulfonate,perfluorononanoic-acid,perluorodecanoic-acid,perfluoroundecanoic-acid,perfluorodecanesulfonate,perfluorododecanoic-acid and perfluorotetradecanoic acid)in meat by ultra performance liquid chromatography-tandem mass spectrometry(UPLC-MS/MS) with solid phase extraction column.After added with the isotopic labeled sodium perfluoro-1-［1,2,3,4,-13C4］octanesulfonat (MPFOA) and perfluoro-n-［1,2,3,4,-13C4］octanoic acid (MPFOS),the samples were extracted and homogenized with acetonitrile,and then suction filted through glass fiber and defatted with n-hexane by liquid-liquid extraction method.The extract was purified with Waters Oasis HLB solid phase extraction column,and concentrated with N2.The perfluorinated compounds were separated with UPLC using a mixture of 2 mmol/L ammonium acetate-2 mmol/L ammonium acetate methanol solution as mobile phase,and analysed by UPLC-MS/MS ESI(-) under MRM mode with the internal standard method.The calibration curves were linear in the range of 0.50-20.0 μg/L for 11 PFCs.The limits of detection for the method (LODs) were between 0.014 μg/kg and 0.060 μg/kg,and the limits of quantitation were between 0.047 μg/kg and 0.199μg/kg.The mean recoveries were in the range of 70.9%-107.1%,with relative standard deviations (RSDs,n=6) of 0.4% -11.4%.This method was suitable for the identification and quantification of 11 perfluorinated compounds in meat due to its simplicity,accuracy and high sensitivity.