Simultaneous Determination of Dopamine,Uric Acid and Nitrite Using Poly(2-oxygen amino methyl-2-(2-amino thiazole)-4-acetic acid) Modified Electrode

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Simultaneous Determination of Dopamine,Uric Acid and Nitrite Using Poly(2-oxygen amino methyl-2-(2-amino thiazole)-4-acetic acid) Modified Electrode

- Simultaneous Determination of Dopamine,Uric Acid and Nitrite Using Poly(2-oxygen amino methyl-2-(2-amino thiazole)-4-acetic acid) Modified Electrode
- Vol. 33, Issue 5, Pages: 512-519(2014)
- 作者机构：
  
  上海师范大学生命与环境科学学院化学系
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Simultaneous Determination of Dopamine,Uric Acid and Nitrite Using Poly(2-oxygen amino methyl-2-(2-amino thiazole)-4-acetic acid) Modified Electrode. [J]. 33(5):512-519(2014)
DOI：

Simultaneous Determination of Dopamine,Uric Acid and Nitrite Using Poly(2-oxygen amino methyl-2-(2-amino thiazole)-4-acetic acid) Modified Electrode. [J]. 33(5):512-519(2014) DOI：

摘要

采用循环伏安法(CV)将2-甲氧氨基-2-(2-氨基噻唑)-4-乙酸(AMTA)聚合修饰在玻碳电极(GCE)表面，制备了聚2-甲氧氨基-2-(2-氨基噻唑)-4-乙酸修饰的玻碳电极(PAMTA/GCE)。在pH 7.0的生理性磷酸盐缓冲溶液(PBS)中，PAMTA/GCE不仅能很好地改善多巴胺(DA)、尿酸(UA)和亚硝酸根(NO-2)的电化学行为，而且能将三者的混合液在裸GCE上重叠的弱氧化峰分成3个灵敏的氧化峰，故该修饰电极可用于对混合液中DA、UA和NO-2的同时测定。在优化实验条件下，DA、UA和NO-2的差分脉冲伏安峰电流与其浓度分别在0.3~75、1~480、20~1 680 μmol/L范围内呈良好的线性关系，相关系数分别为0.989 9、0.957 1和0.992 7，检出限(3δ)分别为0.05、0.10、0.30 μmol/L。将PAMTA/GCE应用于尿液和血清样本中DA、UA和NO-2的同时测定，结果满意。

Abstract

A poly(2-oxygen amino methyl-2-(2-amino thiazole)-4-acetic acid(PAMTA)modified glassy carbon electrode(PAMTA/GCE) was fabricated by CV method.In 0.1 mol/L pH 7.0 PBS buffer,PAMTA/GCE not only improved the oxidations of DA,UA and NO-2,but also resolved the weak and overlapped voltammetric responses of DA,UA and NO-2 into three sensitive oxidation peaks.Thus,the modified electrode can be used for the simultaneous determination of these species.Under the optimum conditions,the linear concentration dependences of DPV current responses were observed for DA,UA and NO-2 in the concentration ranges of 0.3-75 μmol/L,1-480 μmol/L and 20-1 680 μmol/L,with correlation coefficients of 0.989 9,0.957 1 and 0.992 7,respectively.The detection-limits(3δ) were 0.05,0.10,0.30 μmol/L for DA,UA and NO-2,respectively.The modified electrode was used for simultaneous determination of DA,UA and NO-2 in human urine and serum samples with satisfactory results.

关键词

多巴胺尿酸亚硝酸盐2-甲氧氨基-2-(2-氨基噻唑)-4-乙酸

Keywords

dopamineuric acidnitrite2-oxygen amino methyl-2-(2-amino thiazole)-4-acetic acid

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