A high performance liquid chromatographic method was developed for the simultaneous determination of ten synthetic cannabinoids in novel“spice”drugs.A Shim-pack XR-ODS C18（4.6 mm×250 mm，5 μm） column was used at 45 ℃.The mobile phase system contained methanol-acetonitrile（50∶50） and water,and the percentage of organic phase changed between 66% and 89.1% in a linear gradient elution.The flow rate was set at 1.0 mL/min,and the detection wavelength was 220 nm.Under the optimized conditions,ten synthetic cannabinoids were completely separated and determined in 33 min.Good linear relationships were obtained in the range of 1-100 mg/L with correlation coefficients of 0.999 9.The LODs were in the range of 0.10-0.50 mg/L.The intra-day relative standard deviations（RSDs） were in the range of 0.15%-1.37% and the inter-day RSDs were 0.55%-1.96%.The sample showed good stability under room temperature,freeze and three cycles of freeze-thaw conditions.This method was accurate,sensitive and rapid for the determination of common synthetic cannabinoids in novel“spice”drugs.