A class-specific molecularly imprinted polymer(MIP) with strong selectivity and adsorbability for triazines and their metabolites was synthesized by bulk polymerization using atrazine as template molecule,methacrylate acid(MAA) as functional monomer,and trimethylolpropane trimethacrylate(TRIM) as cross-linker. And a rapid method was developed for the determination of 8 triazines and their metabolites in maize,wheat and cotton samples by molecularly imprinted solid phase extraction and high performance liquid chromatography tandem mass spectrometry(MISPE/HPLC-MS/MS).The proportion of atrazine and methacrylate acid was screened and optimized by ultraviolet spectrometry.The morphology of polymer was observed with scanning electron microscope and transmission electron microscope.The recognition performance of structure analogues on the molecularly imprinted polymer was studied by HPLC-MS/MS.The result indicated that the synthesized molecularly imprinted polymer had a strong affinity and specificity for atrazine and its structure analogues,and the molecularly imprinted solid phase extraction cartridge had a good selectivity and purifying ability.The mean recoveries of these compounds in maize,wheat and cotton were in the range of 61.1%-107.6%,with relative standard deviations(RSD) below 11%.The limits of detection(S/N=3) were in the range of 0.4- 8.1 μg/kg. The MISPE-HPLC-MS/MS method could be applied in the routine surveillance of actual samples.
关键词
三嗪类农药类特异性分子印迹聚合物固相萃取高效液相色谱-串联质谱(HPLC-MS/MS)残留量
Keywords
triazine pesticidesclass-specificmolecularly imprinted polymersolid phase extractionhigh performance liquid chromatography tandem mass spectrometry(HPLC-MS/MS)residue
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河南科技学院食品学院
唐山师范学院化学系
河北科技大学生物科学与工程学院
Key Laboratory of Pesticide Environmental Assessment and Pollution Control,Ministry of Environmental Protection,Nanjing Institute of Environmental Sciences,Ministry of Ecology and Environment of the People’s Republic of China
College of Carbon Neutral Modern Industry,College of Environmental and Resource Science,Fujian Normal University