A method for the determination of albendazole（ABZ） by resonance Rayleigh scattering（RRS）,second-order scattering（SOS） and frequency doubling scattering（FDS） at the nanogram level using 12-tungstophosphoric acid（TP） was presented.It was found that ABZ could react with TP and form an ion-association complex by 3∶1 in pH 1.2 HCl medium,which induced the enhancement of RRS,SOS and FDS intensities.In certain ranges,the increments of scattering intensity（ΔI） were directly proportional to the concentrations of ABZ.The detection limits（3σ） for ABZ were 1.98 μg/L（RRS）,3.75 μg/L（SOS） and 5.07 μg/L（FDS）,respectively.The sensitivity of RRS method was higher than that of SOS and FDS methods.The optimum conditions of RRS method and the influencing factors were discussed.In addition,the composition of ion-association complex and the reaction mechanism were investigated.With a good selectivity,the method was successfully applied for the determination of ABZ in tablets and human urine samples with satisfactory results.