Determination of Methimazole Using Gold Nanoparticles Catalyzed Luminol Chemiluminescence System

您当前的位置：

首页 >

文章列表页 >

Determination of Methimazole Using Gold Nanoparticles Catalyzed Luminol Chemiluminescence System

- Determination of Methimazole Using Gold Nanoparticles Catalyzed Luminol Chemiluminescence System
- Vol. 33, Issue 5, Pages: 557-560(2014)
- 作者机构：
  
  1. 榆林学院化学与化工学院
  2. 延安大学化学与化工学院
- 作者简介：
- 基金信息：
- DOI：
  CLC：
扫描看全文
Determination of Methimazole Using Gold Nanoparticles Catalyzed Luminol Chemiluminescence System. [J]. 33(5):557-560(2014)
DOI：

Determination of Methimazole Using Gold Nanoparticles Catalyzed Luminol Chemiluminescence System. [J]. 33(5):557-560(2014) DOI：

摘要

在碱性介质中，甲巯咪唑能强烈增敏纳米金-鲁米诺-硝酸银化学发光体系产生较强的化学发光信号，据此建立了一种流动注射化学发光测定甲巯咪唑的新方法。在优化实验条件下，该方法对甲巯咪唑的检测线性范围为1.0×10-9~1.0×10-8、1.0×10-8~1.0×10-7、1.0×10-7~1.0×10-6 g/mL，检出限（S/N=3）为3.0×10-10 g/mL，相对标准偏差为1.2%（n=11，ρ=1.0×10-8 g/mL）。将该法用于药物中甲巯咪唑含量的测定，结果满意。同时，采用化学发光光谱表征技术对该体系的化学发光反应机理进行了初步探讨。

Abstract

A novel method for the determination of methimazole was proposed,based on its enhancement effect on the luminol-silver nitrate-gold nanoparticles（AuNPs） chemiluminescence（CL） system in alkaline medium.The experimental conditions were studied.Under the optimal experimental conditions,methimazole could be detected in 3 sectional linear ranges of 1.0×10-9-1.0×10-8,1.0×10-8-1.0×10-7，1.0×10-7-1.0×10-6 g/mL with a detection limit of 3.0×10-10g/mL,and relative standard deviation was 1.2%（n=11，ρ=1.0×10-8 g/mL）.The method was successfully applied in the determination of methimazole in pharmaceutical formulations.In addition,the mechanism of gold nanoparticles-luminol-AgNO3 system was also explored by the CL spectrum.

关键词

甲巯咪唑化学发光纳米金

Keywords

methimazolechemiluminescencegold nanoparticles

references

Views

1007

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Rapid Determination of Aniline by Gold Nanoparticles enhanced Low Temperature Plasma Ionization Mass Spectrometry

Sensitive Detection of Aflatoxin B1 in Traditional Chinese Medicine Using an Aptasensor Based on Enzyme-assisted Target Recycling

High Sensitive Detection of HIV-DNA by Cascade Chemiluminescence Signal Amplification Strategy Based on Microchip Electrophoresis Platform

An Electrochemical Biosensor Based on a DNA Tetrahedral Nanostructure Probe for Detection of DNA Methylation

Related Author

No data

Related Institution

清华大学化学系

南京医科大学药学院

国家卫健委核医学重点实验室江苏省分子核医学重点实验室江苏省原子医学研究所

药用资源化学与药物分子工程省部共建国家重点实验室

Address：100 Xianlie Middle Road, Guangzhou Postal code：510070
Tel：020-87684776,37656606 Fax：020-87684776 Email：fxcsxb@china.com
Technical support is provided by Beijing Founder electronics co., LTD 粤ICP备12017312号-3 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰