An effective method was established for the simultaneous determination of the residual contents of 12 glycol ethers in leather and its products.Glycol ethers in leather and leather products were microwave-assisted extracted at 85 ℃,using methanol as extraction solvent.The extracts were purified with solid phase extraction(SPE) column,and analyzed by gas chromatography-mass spectrometry/selected ions monitoring technique(GC-MS/SIM) with the external standard method.The spiked average recoveries varied from 81.1% to 95.9% with relative standard deviations(RSDs) of 1.4%-9.6%.The limits of quantitation(LOQ,S/N=10) for analytes were in the range of 0.05-0.20 mg/kg.The proposed method was simple,rapid,sensitive and accurate,and could satisfy completely the technical demands for the determination of glycol ethers residual in leather and its products and provide a reference for the relevant testing standard.