An analytical method was established for the simultaneous determination of residues of abamectin，emamectin benzoate，imidacloprid，indoxacard，zineb in vegetables by ultra high pressure liquid chromatography-tandem mass spectrometry(UPLC-MS/MS).The samples were extracted with acetonitrile after treated with 0.1% NaOH(containing 10 mmol/L L-cysteine and 10 mmol/L EDTA-Na2)，and cleaned up by 0.2 g C18+0.05 g GCB matrix dispersive solid phase extraction.Five kinds of pesticides were separated on a Thermo Hypersil BDS C18(100 mm × 4.6 mm，2.6 μm) column using 10 mmol/L NH4OH-acetonitrile as mobile phase by gradient elution，and determined by MS/MS.The results showed that the calibration curves were linear in the ranges of 50-2 000 μg/L for zineb，and 5-200 μg/L for the rest of analytes.The correlation coefficients were in the range of 0.995 1-0.999 9.The spiked concentration ranges were 0.5-500 μg/kg for five compounds in bean，chilli，pakchoi，cucumber，asparagus and tomato samples，and the spiked recoveries were in the range of 70.8%-103.6% with relative standard deviations(RSD) of 4.5%-13.9%.The limits of detection for zineb ranged from 8.2 μg/kg to 30 μg/kg,and the limits of quantitation were in the range of 27-100 μg/kg.The limits of detection for the rest of compounds were in the range of 0.02-0.7 μg/kg,and the limits of quantitation were 0.07-2.3 μg/kg.The method was rapid，accurate，economical and practical，and could meet the needs of daily inspection.