A high performance liquid chromatography-tandem mass spectrometric(LC-MS/MS) method was developed for the determination of eight kinds of drugs(4-chlorophenoxyacetic acid，indole-3-acetic acid，2,4-dichlorophenoxyacetic acid，indole-3-butyric acid，1-naphthlcetic acid，gibberellin acid，6-benzylaminopurine and carbendazim) in sprouts.The samples were extracted with acetonitrile containing 0.1% acetic acid，concentrated and cleaned up with dispersive solid phase extraction powder.The extract was analyzed by LC-MS/MS.The linear ranges of eight compounds ranged from 5 μg/L to 100 μg/L with correlation coefficients(r2) more than 0.99.The limits of quantitation of eight compounds were 5 μg/kg.At three spiked concentration levels of 5，10，20 μg/kg，the recoveries of eight compounds ranged from 71.6% to 87.9% with relative standard deviations(RSDs) not more than 14.6%.The method was accurate，simple and quick，and was suitable for the simultaneous determination of eight compound residues in sprouts.