Taking into account the high number of synthetic cannabinoids found in seized novel “spice” drugs in recent years,this study aimed at the simultaneous determination of common synthetic cannabinoids.An HPLC-MS/MS method was developed for the determination of ten synthetic cannabinoids in novel “spice” drugs.Samples were dissolved with methanol,and then ultrasound assistedly extracted and filtered through a 0.22μm membrane filter.The extract was separated on an Agilent Poroshell 120 EC-C18(3.0mm×50mm，2.7μm) column at 30℃,using methanol-water as mobile phase.The flow rate was set at 0.3mL/min.ESI+ and ESI- mode were used at different times,and the MS spectra characteristics and proposed fragmentation of 10 synthetic cannabinoids were studied.Under the optimized conditions,good linear relationships were obtained in the ranges of 1-100ng/mL for 7 synthetic cannabinoids under ESI+ mode,and 10-1000ng/mL for 3 synthetic cannabinoids under ESI- mode.The intra-day relative standard deviations(RSDs) were not more than 3.2% and the inter-day RSDs were not more than 6.3%.This method was applied in real cases,and was proved to be fast,accurate,sensitive and precise for the determination of those 10 common synthetic cannabinoids in novel “spice” drugs.