Development of a C-Reactive Protein Immunosensor Based on Au Nanoparticles/Reduced Graphene Oxide

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Development of a C-Reactive Protein Immunosensor Based on Au Nanoparticles/Reduced Graphene Oxide

- Development of a C-Reactive Protein Immunosensor Based on Au Nanoparticles/Reduced Graphene Oxide
- Vol. 36, Issue 3, Pages: 349-354(2017)
- 作者机构：
  
  云南师范大学化学化工学院
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Development of a C-Reactive Protein Immunosensor Based on Au Nanoparticles/Reduced Graphene Oxide. [J]. 36(3):349-354(2017)
DOI：

Development of a C-Reactive Protein Immunosensor Based on Au Nanoparticles/Reduced Graphene Oxide. [J]. 36(3):349-354(2017) DOI：

摘要

采用还原氧化石墨烯-金纳米颗粒（RGO-Au NPs）作为免疫传感器的固定基质，将Ｃ-反应蛋白（CRP）抗体固定在玻碳电极表面，用蒽醌二羧酸作为标记物，制成夹心型的CRP免疫传感器。在最优实验条件下，通过示差脉冲伏安法对CRP的含量进行检测。该传感器在0.25~100 ng/mL范围内具有良好的线性关系，检出限为0.08 ng/mL，线性系数为0.997。该传感器为C-反应蛋白的检测提供了一种新的手段。

Abstract

In this paper，Au nanoparticles（Au NPs）/reduced graphene oxide（RGO） was used as the matrix of immunosensor to immobilize c reactive protein（CRP） antibody on the surface of glassy carbon electrode.A sandwich immunosensor was constructed using quinone dicarboxylic acid as tag.Under the optimal experiment conditions，the concentration of CRP was detected by differential pulse voltammetry.The linear range is 0.25-100 ng/mL with a detection limit of 0.08 ng/mL and a correlation coefficient of 0.997.This immunosensor provides a new simple means for the determination of c reactive protein.

关键词

夹心型免疫传感器Ｃ-反应蛋白（CRP）还原氧化石墨烯电化学

Keywords

sandwich immunosensorc reactive protein（CRP）reduced graphene oxideelectrochemistry

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Key Laboratory of Low-carbon Chemistry & Energy Conservation of Guangdong Province，Sun Yat-sen University

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Key Laboratory of Environmental Functional Materials of Yunnan Province Education Department，School of Chemistry and Environment，Yunnan Minzu University

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