Synthesis and Antibacterial Properties of Imidazole Substituted Hydroxyl Quaternary Ammonium Salt

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Synthesis and Antibacterial Properties of Imidazole Substituted Hydroxyl Quaternary Ammonium Salt

- Synthesis and Antibacterial Properties of Imidazole Substituted Hydroxyl Quaternary Ammonium Salt
- Vol. 35, Issue 5, Pages: 595-599(2016)
- 作者机构：
  
  滨州医学院药学院
- 作者简介：
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Synthesis and Antibacterial Properties of Imidazole Substituted Hydroxyl Quaternary Ammonium Salt. [J]. 35(5):595-599(2016)
DOI：

Synthesis and Antibacterial Properties of Imidazole Substituted Hydroxyl Quaternary Ammonium Salt. [J]. 35(5):595-599(2016) DOI：

摘要

将咪唑基团与N-甲基二乙醇胺进行季铵化反应，经过重结晶纯化得到2-(2-羟乙基)-甲基-(1-甲基-1H-咪唑-2-亚甲基) 氯化铵(QAS-1)，以傅立叶变换红外光谱(FT-IR)、核磁共振(NMR)和飞行时间质谱(TOF-MS)等进行结构表征。并采用纸片法和振荡培养法初步研究了QAS-1对金黄色葡萄球菌(S-aureus)、甲型链球菌(α-H-tococcus)、大肠杆菌(E-coli)、绿脓杆菌(P-aeruginosa)等菌种的抗菌性能。结果显示，季铵盐QAS-1对这4种菌均显示较好的抗菌活性，特别是对革兰氏阴性菌(E-coli，P-aeruginosa)的杀菌效果更加显著，且优于阳性药(葡萄糖酸氯己定)。

Abstract

In this paper,the quaternary ammonium salt(QAS-1) was prepared with N-methy imidazole and N-methyl diethanol amine.It was characterized by FT-IR,NMR and TOF-MS.Its antibacterial properties against S-aureus,α-H-tococcus,E-coli and P-aeruginosa were subsequently evaluated by paper disk method and shake culture method,which showed that it has a good antibacterial effect.Especially,the antibacterial effect against gram-negative bacteria(E-coli and P-aeruginosa) is more obvious and better than positive control(chlorhexidine).

关键词

季铵盐N-甲基咪唑抗菌活性细胞毒性

Keywords

quaternary ammonium salt(QAS)N-methyl imidazoleantibacterial propertiescytotoxicity

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