A method was developed for the screening,confirmation and quantification of perfluorinated compounds in textiles by liquid chromatography-ion trap-time of flight-tandem mass spectrometry (LC-MS-IT-TOF) combined with dispersive solid phase extraction.The multiple stage fragments ion mass spectrometry database of 14 target compounds was established.The analytes in samples were extracted with methanol under ultrasonic extraction,and the extract was cleaned up with a C18 sorbents.In the chromatographic analysis,14 target compounds were separated on a C8 chromatographic column(150mm×4.6mm,3.5μm) by gradient elution using methanol-5mmol/L ammonium acetate as mobile phase.The effects of species and dosages of the sorbents on recoveries of 14 target compounds were studied,and the purification conditions were optimized.The results showed that the method detection limits of the target compounds ranged from 1μg/kg to 10μg/kg. The average recoveries of 14 compounds at three spiked concentration levels(10,50,100μg/kg) were in the range of 49.2%-101.4% with relative standard deviations(RSDs) of 1.1%-14.0%．The screening of analytes was performed by precision mass matching acquired by full scanning and library searching.The confirmatory analysis for target compounds was performed with the retention time and qualitative fragments.This method is simple,fast,credible and highly sensitive.It could be applied in the simultaneous screening and identification of perfluorinated compounds in textiles.