A simple and rapid method was established for the determination of total iodine in different infant formulas by oven fast digestion with KOH solution combined with inductively coupled plasma mass spectrometry(ICP-MS).Concentration of KOH solution and temperature of digestion were optimized,and the stability of the digestion solution was investigated.The result indicated that the infant formula samples could be completely digested with 5% KOH solution in 1 h under 105 ℃,and the iodine ion could be stable for 48 h in the stabilizer of ammonia-Na2S2O3 solution.Using 141Pr as the internal standard,the iodine contents of the filtrate were determined by inductively coupled plasma mass spectrometry(ICP-MS).The method could reduce the complex sample processings such as pretreatment precipitation and derivative extraction compared with the national standard method(GB 5413.23-2010).Iodine presented favorable linearity in the range of 0-100 μg/L with correlation coefficient(r) of 1.000 0,and the method detection limit was 1.5 μg/kg.By means of determing the national standard material GBW 10017,NIST SRM 1849a and milk powders with different matrices,recoveries of 88.2%-107.4% were obtained and RSDs for repeatability and reproducibility were less than 5%.The iodine determined by the national standard material GBW 10017 and NIST SRM 1849a presented no significant differences between measured values and certified values.The method showed the advantages of sensitivity,accurancy and satisfactory recovery,and was suitable for the determination of total iodine in different infant formula matrices.