Discovery and Structure Identification of a New Phosphodiesterase-5 Inhibitor  Derivative

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Discovery and Structure Identification of a New Phosphodiesterase-5 Inhibitor Derivative

- Discovery and Structure Identification of a New Phosphodiesterase-5 Inhibitor Derivative
- Vol. 35, Issue 5, Pages: 551-556(2016)
- 作者机构：
  
  河北省药品检验研究院
- 作者简介：
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Discovery and Structure Identification of a New Phosphodiesterase-5 Inhibitor Derivative. [J]. 35(5):551-556(2016)
DOI：

Discovery and Structure Identification of a New Phosphodiesterase-5 Inhibitor Derivative. [J]. 35(5):551-556(2016) DOI：

摘要

基于超高效液相色谱电喷雾四极杆飞行时间串联质谱联用(UPLC-DAD-QTOF-MS)技术检出某保健酒中非法添加了一种磷酸二酯酶-5(PDE-5)抑制剂衍生物，经制备液相色谱分离纯化，采用UPLC-DAD-QTOF-MS、核磁共振(NMR)和红外光谱(IR)技术对其进行了分析和结构鉴定，确定其为一种新型艾地那非衍生物，国内外均未见报道。

Abstract

One suspected phosphodiesterase-5 inhibitor(PDE-5) derivative was found in a kind of medicinal liquor by UPLC-DAD-QTOF-MS.Sample purification was carried out by a preparative HPLC system，and its structure was determined by NMR,IR and UPLC-DAD-QTOF-MS methods.The results showed that the compound is a new aildenafil derivative which has never been reported at home and abroad.

关键词

磷酸二酯酶-5(PDE-5)抑制剂衍生物UPLC-QTOF-MSNMRIR结构鉴定

Keywords

PDE-5 inhibitor analogueUPLC-QTOF-MSNMRIRstructure identification

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Hubei Provincial Engineering and Technology Research Center for Food Quality and Safety Test，Hubei Provincial Institute for Food Supervision and Test

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