A method for the analysis of polybrominated diphenyl ethers(PBDEs) in urine of occupational worker was developed using QuEChERS(quick，easy，cheap，effective，rugged，safe) pretreatment coupled to gas chromatography-mass spectrometry(GC-MS).Urine sample was extracted with an acetone-hexane mixture by dehydration and salting-out using NaCl and anhydrous MgSO4.The purification was performed with C18 particlet,and GC-MS determination was perfomed under negative chemical ionization(NCI) mode.The calibration curves were linear in the ranges of 10-1 000 pg/μL for BDE-209，and 1-100 pg/μL for the rest of analytes，with correlation coefficients higher than 0.999 .The average recoveries were in the range of 91.7%-110.2% at three spiked levels，with relative standard deviations lower than 10%.The limits of detection(LOD) of PBDEs ranged from 0.3 pg/mL to 36 pg/mL.This method was validated to be simple，sensitive and selective，and was suitable for the exposure accessment of pollutant in occupational workers.