A new magnetic molecularly imprinted polymers(MIPs) were prepared by using Fe3O4@SiO2 as the support,4-vinyl pyridine(4-VP) as functional monomer,bisphenol A(BPA) as template molecule through surface molecularly imprinted polymerization technology.The structure and morphology of Fe3O4@SiO2-MIPs were characterized by infrared spectroscopy(IR)and transmission electron microscopy(TEM).A new method was established for the separation and enrichment of BPA in milk sample by molecularly imprinted magnetic solid-phase extraction combined with high performance liquid chromatography(HPLC) using Fe3O4@SiO2-MIPs as magnetic adsorbent.The results showed that the Fe3O4@SiO2-MIPs has a high selectivity for BPA under the optimized experimental condition,and the adsorption capacity of Fe3O4@SiO2-MIPs was 13.50 mg/g.The calibration curve of BPA was linear in the range of 0.05-5.0 mmol/L with a correlation coefficient(r2) of 0.993 4.The limit of detection(LOD) was as low as 0.037 μg/L.The proposed method was successfully applied in the determination of BPA in milk sample,with average recoveries of 86.2%-93.1%and relative standard deviations(RSDs) of 2.9%-3.8%at three spiked levels.The developed method is rapid and selective,and is adaptable to the analysis of trace BPA in milk sample.