A method for the determination of 122 pesticide residues in fruits and vegetables from the Hong Kong’s regulation was developed by QuEChERS combined with ultra performance liquid chromatography-tandem mass spectrometry(UPLC-MS/MS). The quantification and confirmation was achieved by electrospray ionization(ESI) in positive and negative ion mode using multiple reaction monitoring(MRM) mode, and the analytes were quantified by the external standard method. The standard curves of 122 target compounds were linear in the range of 0.010-0.20mg/L,with correlation coefficients(r) not less than 0.99.The limits of quantitation(LOQ) were 0.010mg/kg. The recoveries at three spiked levels were in the range of 60%-110% with RSDs of 1.8% and 19.4%.The method had the advantages of rapidness,simplicity,time-saving,high sensitivity and good stability, and could significantly reduce the test cost.