More and more attention has been paid to the security of dairy products in recent years.Veterinary drug residue is an important part of chemical hazards so that the research on detection technology has always been a hotpot of dairy products safety analysis.Liquid chromatography-mass spectrometry(LC-MS) has become a mainstream in veterinary drug residues analysis because of its special advantages of sensitivity and selectivity.The veterinary drug residues analysis based on LC-MS has been developed into multiclass and multiresidue stages gradually.While the differences of physicochemical properties,residual station and limited quantity exist among the multiclass veterinary drugs,both the sample pretreatment and subsequent instrument analysis have come across certain technological difficulties.To know more about the research development in this field,the literatures concerning the multiresidue determination of veterinary drugs in dairy products using LC-MS at home and abroad in resent years are summarized in this paper,from several aspects including sample pretreatment,LC-MS detection and matrix effect.