An ultra performance liquid chromatography-tandem mass spectrometric(UPLC-MS/MS) method with solid phase extraction(SPE) was applied in the simultaneous determination of phenylbutazone and aminopyrine in anti-acne cosmetics.The sample was ultrasonically extracted with acetonitrile,and then purified on an Oasis HLB solid phase extraction column.The separation was performed with an Eclipse XDB-C18(3.5 μm，4.6 mm×150 mm) column,using a mixture of methanol and 10 mmol?L-1 ammonium acetate as mobile phase by gradient elution at a flow rate of 0.5 mL?min-1.The analytes were detected with electrospray ionization source in positive ion mode(ESI+) and multiple reaction monitoring(MRM),and quantified by matrix standard curve.The calibration curves of phenylbutazone and aminopyrine were linear in the range of 2.0-200.0 μg?L-1 with correlation coefficients(r2) larger than 0.99.The limits of detection(LOD) and limits of quantitation(LOQ) of the method were 1.5,0.8 μg?kg-1 and 4.9,2.7 μg?kg-1,respectively.The recoveries of phenylbutazone and aminopyrine were in the range of 77.8%-93.4%at three spiked levels,with intra-day and inter-day relative standard deviations(RSD) of 2.4%-7.8% and 3.6%-9.5%,respectively.With fast detection,high sensitivity and low detection limit,the method is able to provide a scientific basis and a technical support for monitoring residues of phenylbutazone and aminopyrine in cosmetics and product quality control.