With the development of chromatography and hyphenated techniques,the automated,high-throughput and rapid analysis becomes a developing trend in future.For the analysis of complex chromatographic data,the chemometric techniques based on mathematical separation have gained increasing attention.However,the previous chemometric methods cannot fully realize the automatic analysis on complex chromatographic signals.Therefore,a number of automated analysis methods are proposed.For the automated analysis of complex one-dimensional chromatographic data,two-dimensional and multi-dimensional data from the hyphenated techniques,the chemometrics methods are mainly divided into four categories: automatic chromatographic peak detection,background and baseline drift correction,chromatographic peak alignment and resolution of multicomponent overlapping signals.The principles and applications of chemometrics methods in chromatographic analysis of complex systems in recent ten years are summarized in this paper.Meanwhile,their advantages and disadvantages are also discussed.Finally,based on the existing problems,the future research focuses on automated analysis of complex chromatographic signals in this area are proposed at the end of the review.