A rapid analytical method was developed for the screening of 14 carcinogenic and sensitizing colorants in toys(e.g. crayon, temporary tattoo sticker and modeling clay) using ionization coupled with ion mobility spectrometry. Without any tedious pretreatment, sampling, extraction and ionization were integrated by paper spray or extraction nano-electrospray. The instrumental analysis time for a single ion mobility spectrometry run was less than 16ms.The suspicious positive samples were subjected to further verification by ultra-performance liquid chromatography-tandem mass spectrometry(UPLC-MS/MS).The limits of detection(LODs) for the 14 carcinogenic and sensitizing colorants in toys ranged from 0.5mg/kg to 2mg/kg.The established method is simple, convenient and suitable for rapid, on-site screening of toy products.