Molecularly imprinted polymers were synthesized by atom transfer radical polymerization with fragment imprinting technique with the structural analogue of sulfonamide,4,6-dichloropyrimidine as template.The imprinted polymers were synthesized using 4,6-dichloropyrimidine (template),glycidyl methacrylate(functional monomer) and 2,2′- bipyridine(ligand) by the molar ratio of 10∶180∶1 at a reaction temperature of 60 ℃ and a reaction time of 5 h.The adsorption capacity for the synthetic imprinted polymers was 1.48 mg/g while that for non-imprinted polymers was 0.73 mg/g. The synthetic polymers were used as a new material for the selective separation and enrichment of veterinary drug residues in samples.The results showed that the selective adsorption capacity for the imprinted polymers was better than that for the non-imprinted polymers.The surface morphology of the polymers was characterized by scanning electron microscopy.