An effective method was established for the determination of eight ethylene glycol ethers in cosmetics by gas chromatography-mass spectrometry(GC-MS).Samples were ultrasonically extracted with methanol.The extracts were filtered,and analyzed by GC-MS.The quantitation was carried out by the external standard method.The eight target compounds were baseline separated under optimized chromatographic conditions.Good linearities were obtained in respective linear ranges,with correlation coefficients all larger than 0999.The mean recoveries at three spiked levels ranged from 822% to 1130% with relative standard deviations(RSDs) of 060%-85%.The limits of detection(LODs) were in the range of 010-100 mg/kg and the limits of quantitation(LOQs) were 025- 200 mg/kg.The method is simple,accurate,reliable and reproducible,and could be applied in the determination of ethylene glycol ethers in cosmetics.
关键词
气相色谱-质谱化妆品乙二醇醚类物质
Keywords
gas chromatography-mass spectrometry(GC-MS)cosmeticsethylene glycol ethers
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Guangdong Provincial Key Laboratory of Chemical Measurement and Emergency Test Technology,Guangdong Provincial Engineering Research Center for Quality and Safety of Traditional Chinese Medicine,Institute of Analysis,Guangdong Academy of Sciences(China National Analytical Center,),Guangzhou
Guangzhou Institute for Drug Control
Institute of Analysis,Guangdong Academy of Sciences(China National Analytical Center,Guangzhou),Guangdong Provincial Key Laboratory of Chemical Measurement and Emergency Test Technology,Guangdong Provincial Engineering Research Center for Quality and Safety of Traditional Chinese Medicine
Guangdong Institute for Drug Control,National Medical Products Administration Key Laboratory for Safety Risk Assessment of Cosmetics
Guangzhou Quality Supervision and Testing Institute,National Quality Supervision and Testing Center for Cosmetics(),Guangzhou