In this work,an Ag nanoparticles-graphene composite nanomaterial(AgNPs-GN) was prepared by redox reaction.And an Ag nanoparticles-graphene modified glass carbon electrode(AgNPs-GN/GCE) was fabricated by immobilizing AgNPs-GN on the surface of the glass carbon electrode.The electrochemical behaviors of paracetamol on AgNPs-GN/GCE and GN/GCE were investigated in B-R buffer solution(pH 4.78) by cyclic voltammetry and square wave voltammetry.Both modified electrodes had electrocatalytic activity for the redox of paracetamol,and the AgNPs-GN/GCE possessed a more excellent electrocatalytic effect.Under the optimal conditions,the reduction peak current of paracetamol was proportional to its concentration in the range of 1.0×10-7-5.0×10-4 mol/L with the detection limit of 3.0×10-8 mol/L.A new method for the determination of paracetamol in tablets was established.The modified electrode showed an excellent stability and a good reproducibility.