A novel molecular imprinted polymer(MIP) sensor was successfully prepared for selective direct detection of nitrofurantoin in water and feed samples.To obtain the fluorescent sensor,carbon quantum dots(CDs) were synthesized by using citric acid as carbon source,modified with silane agent to introduce polymerizable bonds on the CDs surface,then a nitrofurantoin molecularly imprinted polymer(MIP) nanofilm was attached on the modified CDs surface.The structure and morphology of CDs and MIP-CDs were characterized by fourier transform infrared(FTIR) spectroscopy and scanning electron microscopy(SEM).A series of adsorption experiments were performed to investigate the absorption capacity of MIP-CDs.The results showed that the relationship between fluorescence quenching and nitrofurantoin concentration followed the Stern-Volmer equation with a good linear response in the range of 0-10 mg/L,and the detection limit for nitrofurantoin was 2 μg/L.In addition,the MIP-CDs were employed to detect the nitrofurantoin in water and feed samples with recoveries of 78.0%-95.2% and RSDs not more than 6.4%(n=3).The developed method was simple,rapid and selective,and was suitable for the analysis of trace nitrofurantoin in water and feed samples.