A method for the simultaneous determination of roxarsone(ROX),arsanilic acid(ASA),naphthalene arsenate(NPAA),carbarsone(CBS),arsenate(As Ⅴ),arsenite(As Ⅲ),methyl arsenic acid(MMA),dimethyl arsenic acid(DMA),arsenobetaine(As B) and arsenic choline(As C) was developed by high performance liquid chromatography and inductively coupled plasma mass spectrometry(HPLC-ICP-MS).The sample was extracted with 10% methanol.The HPLC separation was performed on a Dionex IonPac AS7 anion exchange column with ammonium carbonate as mobile phase by gradient elution.Identification and quantification were achieved by ICP-MS.The linear ranges for ten arsenic species compounds were observed from 0.1 μg/L to 100 μg/L with correlation coefficients greater than 0.999.The detection limits of ten arsenic species were in the range of 0.3-1.5 μg/kg and the limits of quantitation were 1.0-5.0 μg/kg.The average recoveries for ten arsenic species spiked at three levels ranged from 81.3% to 97.7% with relative standard deviations of 0.1%-3.5%.With good reproducibility,high sensitivity,the method could extract ten arsenic species in only 5 min with organization grinding oscillation,which was much simpler and more efficient than that with conventional water bath oscillation.The method is suitable for the simultaneous determination of ten arsenic species in chicken and chicken liver.ASA and As Ⅲ were checked out in actual chicken liver samples.