A high performance liquid chromatography-tandem mass spectrometric（HPLC-MS/MS） method was developed for the determination of the migration of 27 perfluorinated compounds in food contact materials using 3% acetic acid,10% alcohol,50% alcohol and olive oil as food simulants. Samples were soaked in 1 L different kinds of food simulants every 6 dm2 food contact materials according to (EU) No10/2011.The water based simulant samples could be analyzed directly after filteration,and the olive oil stimulant samples should be extracted with acetonitrile before analysis. The simulated solution samples were separated on a C18 column with methanol-water as mobile phase,and analyzed under multiple reaction monitoring（MRM） mode.The results showed that there existed good linearities（r＞0999 1） for 27 perfluorinated compounds in the range of 1-1 000 μg/L.The LOQs of PCFs were in the range of 028-985 μg/kg in food simulants.The recoveries for 27 perfluorinated compounds in blank samples at two spiked levels of 10 and 100 ng ranged from 826% to 1121% with relative standard deviations（RSDs） of 22%-75%.