A gas chromatography-mass spectrometric（GC-MS） method was established for the determination of migration quantity of 2,6 dimethylphenol，p tert butylphenol，2,6 di tert butyl 4 methylphenol and butylated hydroxyanisole in food packaging materials，with water，4%（by volume） aqueous acetic acid，50%（by volume） aqueous ethanol and isooctane as the food simulated solution.Samples were soaked with food stimulant，and the water based food simulated soaking solution was extracted with ethyl acetate before analysis，while the isooctane soaking solution was analyzed without any pretreatment.The separation of target compounds was conducted using a DB-1701 capillary（30 m×025 mm×025 μm） column.The determination was performed in selective ion mode，and external standard method was used for quantitation.The results showed that，under optimized conditions，there were good linearities for four phenolic antioxidants between peak areas and concentrations in the range of 01-10 mg/L with correlation coefficients（r） more than 0999.The limits of detection（LOD） of this method were 001 mg/L，and the limits of quantitation（LOQ） were 003 mg/L.The spiked recoveries for four phenolic antioxidants in fruits at three spiked levels of 01，10，100 mg/L ranged from 915% to 110%，with relative standard deviations（RSDs，n=5） of 19%-93%.The method，with the advantages of accuracy，high reliability and sensitivity，was suitable for the determination of migration of four phenolic antioxidants in food packaging materials.