A method based on liquid chromatography-tandem mass spectrometry with accelerated solvent extraction（ASE/LC-MS/MS） was developed for the analysis of niclosamide and its degradation products（5 chlorosalicylic acid and 2 chloro 4 nitroaniline） in sediments.Extraction and cleanup were integrated into one step by accelerated solvent extraction（ASE） with 50 g neutral alumina as within cell adsorbing material,and different temperatures and static times were optimized with acetonitrile-water（3∶1,by volume） as extraction solvents.Under the optimized conditions,the calibration curves for niclosamide and its degradation products were linear in the range of 01-200 μg/L with their correlation coefficients（r） more than 0999.The limits of detection and quantitation of the method were in the ranges of 004-01 μg/kg and 02-05 μg/kg,respectively.The proposed method was applied in the trace analysis of niclosamide and its degradation products in sediments with average recoveries in the range of 935%-1019% at 3 spiked levels of 05,10 and 20 μg/kg,and relative standard deviations of 37%-67%.The method was simple,sensitive and reproducible,and was suitable for the analysis of real sample.