A reliable and sensitive method was developed for the determination of BPA migration in toys by high performance liquid chromatography-tandem mass spectrometry（HPLC-MS/MS）.The migration conditions based on European toy safety standard EN 71-10:2005 with water as simulant were modified.The sample was filtrated with syringe filters made of mixed cellulose esters（MCE）,then directly determined by HPLC-MS/MS.Furthermore,the influences of syringe filters were intensively investigated,and the MCE filters had satisfactory BPA recoveries larger than 90%,whereas other filters made of polyamide（PA,nylon 66）and polyether sulfone（PES）resulted in significant loss of BPA.There existed a good linearity of the method in the range of 2-100 μg·L-1 with correlation coefficients（r2）greater than 0999.The limits of detection（LOD）were in the range of 030-052 μg·L-1,and the limits of quantitation（LOQ）were 100-172 μg·L-1.The spiked recoveries were in the range of 965%-106% with RSDs（n=7）of 20%-86%.The established method was successfully applied in the determination of migration of trace BPA in toys,avoiding the BPA loss caused by improper selection of syringe filters,which could meet the requirements for newly adopted BPA migration limit（004 mg·L-1）specified in the EU Directive 2017/898.