A high sensitivity and throughput method was developed for the simultaneous determination of 152 pesticide residues in vegetables and fruits by gas chromatography tandem mass spectrometry(GC-MS/MS) with QuEChERS-dispersed liquid-liquid microextraction(DLLME).Pesticide residues in vegetables and fruits samples were extracted by QuEChERS method with acetonitrile.Then after centrifugation,the acetonitrile supernatant was added with trace chloroform(CHCl3) for DLLME.The extract was analyzed by(GC-MS/MS) with electron impact ion source(EI) in selective reaction monitoring mode(SRM).Results showed that there were good linear relationships for 152 pesticides including isomers in the range of 5.0-200 μg/L with correlation coefficients above 0.995.The recoveries for the analytes at low,medium and high levels were in the range of 60.6%-119%,with relative standard deviations(RSD,n=6) of 1.5%-20%.The limits of detection and the limits of quantitation were in the ranges of 0.14-2.3 μg/kg and 0.45-7.7 μg/kg,respectively.The method is simple,accurate and sensitive.It is suitable for the high throughput and rapid detection of multi residues in fresh agricultural products such as vegetables and fruits.