A γ aminobutyric acid bonded silica(Sil-GABA) stationary phase was prepared in a green medium with only water as solvent,which was characterized by Fourier transform infrared spectroscopy and elemental analysis.The separation mode and analytical performance of the Sil-GABA stationary phase were evaluated through a series of experiments when it was used as packing material for capillary column.Results showed that three nitrochlorobenzene positional isomers and seven sulfonamides were separated effectively on the Sil-GABA stationary phase with ammonium acetate as mobile phase in an aqueous liquid chromatography mode.Four benzoic acid compounds were separated with high concentrations of organic solvents as mobile phases in a hydrophilic chromatography mode.Additionally,three nitroaniline positional isomers were also separated in a reversed phase chromatography mode.Under the optimal conditions,the relative standard deviations(RSD) of the retention times for the sulfonamides were within 32%,indicating that the Sil-GABA column has a good reproducibility.The prepared Sil-GABA stationary phase could provide potential applications in capillary liquid chromatography with multiple retention mechanisms.