An ultra performance liquid chromatography-tandem mass spectrometric(UPLC-MS／MS) method was developed for the determination of 10 pyrethroid pesticide residues in animal foods.The samples were extracted with glacial acetic acid-acetonitrile（1∶99，by volume），and most of the oil impurities were removed by cryogenic freezing，and then further purified with Z-Sep+ and C18.The separation of target compounds was performed with ACQUITY HSS T3 column using 01% formic acid aqueous solution containing 5 mmol/L ammonium acetate and methanol as mobile phases，and the detection of pesticides was carried out in electrospray ionization under multiple reaction monitoring mode.Results showed that the calibration curves for 10 pyrethroids were linear in the range of 25-100 μg/L with their correlation coefficients all larger than 0997.The limits of detection were in the range of 09-24 μg/kg and the limits of quantitation were 30-80 μg/kg.The spiked recoveries for 10 pyrethroid pesticides at three levels of 10，50 and 100 μg/kg were in the range of 703%- 120% with relative standard deviations（RSDs）of 12%-112%.With simple pretreatment，high sensitivity and good accuracy，the method completed detection on the targets within 10 min，and could meet the requirements for rapid detection of 10 pyrethroid pesticide residues in animal foods.